Census Population Change, 2000–2010
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| Population, April 1, 2000 | Population, April 1, 2010 | Numeric Population Change, 2000 to 2010 | Percent Population Change, 2000 to 2010 | Land Area (square miles), 2010 | Persons Per Square Mile, 2010 | |
| United States | 281,421,906 | 308,745,538 | 27,323,632 | 9.7% | 3,531,905.4 | 87.4 |
| Appalachian Region | 23,642,578 | 25,243,456 | 1,600,878 | 6.8% | 204,452.1 | 123.5 |
| STATE TOTALS | ||||||
| Alabama | 4,447,100 | 4,779,736 | 332,636 | 7.5% | 50,645.3 | 94.4 |
| Georgia | 8,186,453 | 9,687,653 | 1,501,200 | 18.3% | 57,513.5 | 168.4 |
| Kentucky | 4,041,769 | 4,339,367 | 297,598 | 7.4% | 39,486.3 | 109.9 |
| Maryland | 5,296,486 | 5,773,552 | 477,066 | 9.0% | 9,707.2 | 594.8 |
| Mississippi | 2,844,658 | 2,967,297 | 122,639 | 4.3% | 46,923.3 | 63.2 |
| New York | 18,976,457 | 19,378,102 | 401,645 | 2.1% | 47,126.4 | 411.2 |
| North Carolina | 8,049,313 | 9,535,483 | 1,486,170 | 18.5% | 48,617.9 | 196.1 |
| Ohio | 11,353,140 | 11,536,504 | 183,364 | 1.6% | 40,860.7 | 282.3 |
| Pennsylvania | 12,281,054 | 12,702,379 | 421,325 | 3.4% | 44,742.7 | 283.9 |
| South Carolina | 4,012,012 | 4,625,364 | 613,352 | 15.3% | 30,060.7 | 153.9 |
| Tennessee | 5,689,283 | 6,346,105 | 656,822 | 11.5% | 41,234.9 | 153.9 |
| Virginia | 7,078,515 | 8,001,024 | 922,509 | 13.0% | 39,490.1 | 202.6 |
| West Virginia | 1,808,344 | 1,852,994 | 44,650 | 2.5% | 24,038.2 | 77.1 |
| STATE APPALACHIAN TOTALS | ||||||
| Click on the links below to get information on that state's Appalachian Counties. | ||||||
| Appalachian Alabama | 2,837,224 | 3,064,522 | 227,298 | 8.0% | 25,763.0 | 119.0 |
| Appalachian Georgia | 2,207,531 | 2,933,432 | 725,901 | 32.9% | 11,378.2 | 257.8 |
| Appalachian Kentucky | 1,160,627 | 1,184,278 | 23,651 | 2.0% | 18,230.7 | 65.0 |
| Appalachian Maryland | 236,699 | 252,614 | 15,915 | 6.7% | 1,529.0 | 165.2 |
| Appalachian Mississippi | 615,452 | 629,169 | 13,717 | 2.2% | 12,400.1 | 50.7 |
| Appalachian New York | 1,072,786 | 1,066,421 | -6,365 | -0.6% | 11,681.4 | 91.3 |
| Appalachian North Carolina | 1,526,207 | 1,698,908 | 172,701 | 11.3% | 11,886.5 | 142.9 |
| Appalachian Ohio | 2,040,712 | 2,042,040 | 1,328 | 0.1% | 15,978.5 | 127.8 |
| Appalachian Pennsylvania | 5,819,800 | 5,792,195 | -27,605 | -0.5% | 36,444.3 | 158.9 |
| Appalachian South Carolina | 1,028,656 | 1,171,497 | 142,841 | 13.9% | 3,823.9 | 306.4 |
| Appalachian Tennessee | 2,530,610 | 2,785,342 | 254,732 | 10.1% | 20,118.9 | 138.4 |
| Appalachian Virginia | 757,930 | 770,044 | 12,114 | 1.6% | 11,179.3 | 68.9 |
| Appalachian West Virginia | 1,808,344 | 1,852,994 | 44,650 | 2.5% | 24,038.2 | 77.1 |