| | Civilian Labor Force, 2021 | Persons Employed, 2021 | Persons Unemployed, 2021 | Unemployment Rate, 2021 | Unemployment Rate, Percent of U.S. Average, 2021 |
|
| United States | 161,204,000 | 152,581,000 | 8,623,000 | 5.3% | 100.0% |
| Appalachian Region | 12,035,551 | 11,468,696 | 566,855 | 4.7% | 88.0% |
| Alabama | 2,246,993 | 2,169,721 | 77,272 | 3.4% | 64.3% |
| Appalachian Alabama | 1,473,325 | 1,427,352 | 45,973 | 3.1% | 58.3% |
|
| County |
| Bibb | 8,560 | 8,262 | 298 | 3.5% | 65.1% |
| Blount | 25,127 | 24,529 | 598 | 2.4% | 44.5% |
| Calhoun | 46,118 | 44,212 | 1,906 | 4.1% | 77.3% |
| Chambers | 15,752 | 15,173 | 579 | 3.7% | 68.7% |
| Cherokee | 11,808 | 11,512 | 296 | 2.5% | 46.9% |
| Chilton | 19,811 | 19,246 | 565 | 2.9% | 53.3% |
| Clay | 6,095 | 5,930 | 165 | 2.7% | 50.6% |
| Cleburne | 5,890 | 5,739 | 151 | 2.6% | 47.9% |
| Colbert | 23,460 | 22,524 | 936 | 4.0% | 74.6% |
| Coosa | 4,343 | 4,209 | 134 | 3.1% | 57.7% |
| Cullman | 38,858 | 37,943 | 915 | 2.4% | 44.0% |
| DeKalb | 31,097 | 30,308 | 789 | 2.5% | 47.4% |
| Elmore | 37,582 | 36,560 | 1,022 | 2.7% | 50.8% |
| Etowah | 39,262 | 37,658 | 1,604 | 4.1% | 76.4% |
| Fayette | 6,653 | 6,449 | 204 | 3.1% | 57.3% |
| Franklin | 14,304 | 13,941 | 363 | 2.5% | 47.4% |
| Hale | 5,888 | 5,553 | 335 | 5.7% | 106.4% |
| Jackson | 22,975 | 22,316 | 659 | 2.9% | 53.6% |
| Jefferson | 317,359 | 305,782 | 11,577 | 3.6% | 68.2% |
| Lamar | 5,691 | 5,521 | 170 | 3.0% | 55.8% |
| Lauderdale | 42,080 | 40,745 | 1,335 | 3.2% | 59.3% |
| Lawrence | 14,378 | 13,956 | 422 | 2.9% | 54.9% |
| Limestone | 46,572 | 45,430 | 1,142 | 2.5% | 45.8% |
| Macon | 7,948 | 7,471 | 477 | 6.0% | 112.2% |
| Madison | 192,204 | 187,100 | 5,104 | 2.7% | 49.6% |
| Marion | 13,320 | 12,941 | 379 | 2.8% | 53.2% |
| Marshall | 44,714 | 43,644 | 1,070 | 2.4% | 44.7% |
| Morgan | 59,256 | 57,716 | 1,540 | 2.6% | 48.6% |
| Pickens | 7,501 | 7,194 | 307 | 4.1% | 76.5% |
| Randolph | 9,408 | 9,150 | 258 | 2.7% | 51.3% |
| Shelby | 118,212 | 115,683 | 2,529 | 2.1% | 40.0% |
| St. Clair | 41,195 | 40,108 | 1,087 | 2.6% | 49.3% |
| Talladega | 35,695 | 34,215 | 1,480 | 4.1% | 77.5% |
| Tallapoosa | 17,910 | 17,186 | 724 | 4.0% | 75.6% |
| Tuscaloosa | 101,104 | 97,442 | 3,662 | 3.6% | 67.7% |
| Walker | 25,085 | 24,174 | 911 | 3.6% | 67.9% |
| Winston | 10,110 | 9,830 | 280 | 2.8% | 51.8% |
