| | Civilian Labor Force, 2020 | Persons Employed, 2020 | Persons Unemployed, 2020 | Unemployment Rate, 2020 | Unemployment Rate, Percent of U.S. Average, 2020 |
|
| United States | 160,742,000 | 147,795,000 | 12,947,000 | 8.1% | 100.0% |
| Appalachian Region | 12,035,782 | 11,141,797 | 893,985 | 7.4% | 92.2% |
| South Carolina | 2,330,863 | 2,191,331 | 139,532 | 6.0% | 74.3% |
| Appalachian South Carolina | 621,136 | 584,780 | 36,356 | 5.9% | 72.7% |
|
| County |
| Anderson | 88,440 | 83,340 | 5,100 | 5.8% | 71.6% |
| Cherokee | 24,736 | 22,807 | 1,929 | 7.8% | 96.8% |
| Greenville | 251,085 | 237,271 | 13,814 | 5.5% | 68.3% |
| Oconee | 34,191 | 32,421 | 1,770 | 5.2% | 64.3% |
| Pickens | 55,575 | 52,706 | 2,869 | 5.2% | 64.1% |
| Spartanburg | 155,678 | 145,822 | 9,856 | 6.3% | 78.6% |
| Union | 11,431 | 10,413 | 1,018 | 8.9% | 110.6% |
