This report builds on the companion regional study of commodity movements within and between the Appalachian Region and the rest of the world by transportation mode to identify exemplary case studies of intermodal initiatives and opportunities in the Appalachian Region. Examples represent only a sampling of transportation opportunities within the Region. The case studies represent a range of examples, from projects that have already been implemented, to projects that are being planned, to project concepts that are still being evaluated. Taken together, however, these case studies provide concrete examples of how intermodal transportation infrastructure can strategically stimulate and support economic development in Appalachia.